We are compelled to live as the Spirit directs, not as our self-directed nature directs, because if we do the latter we will be eternally separated from God, but if we cease doing the latter we will live eternally.

Romans 8:12-13

12 Therefore, my fellow believers, we must live as the Spirit directs us. What we do not have to do is to live as our self-directed nature guides us. 13 If you live the way your self-directed nature directs, you will surely not live eternally (OR, will surely be eternally separated from God). But if by the power of God’s Spirit you quit doing the sinful things that your bodies desire [MET], you will live eternally.